SLC17A6/7/8 Vesicular Glutamate Transporter Homologs in Nematodes
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چکیده
منابع مشابه
Vesicular glutamate transporter-dependent glutamate release from astrocytes.
Astrocytes exhibit excitability based on variations of their intracellular Ca2+ concentrations, which leads to glutamate release, that in turn can signal to adjacent neurons. This glutamate-mediated astrocyte-neuron signaling occurs at physiological intracellular Ca2+ levels in astrocytes and includes modulation of synaptic transmission. The mechanism underlying Ca2+-dependent glutamate release...
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Dissertation for the award of the degree " Doctor rerum naturalium " (Dr. rer. nat) Herewith I declare, that I prepared this work " Transport mechanisms of the Vesicular Glutamate Transporter 1 " on my own and with no other sources and materials than quoted.
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Exocytotic release of glutamate depends upon loading of the neurotransmitter into synaptic vesicles by vesicular glutamate transporters, VGLUTs. The major isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in synapses of the adult rodent brain that correlates with the probability of release and potential for plasticity. Indeed, expression of different VGLUT protein isoforms c...
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Quantal release of the principal excitatory neurotransmitter glutamate requires a mechanism for its transport into secretory vesicles. Within the brain, the complementary expression of vesicular glutamate transporters (VGLUTs) 1 and 2 accounts for the release of glutamate by all known excitatory neurons. We now report the identification of VGLUT3 and its expression by many cells generally consi...
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ژورنال
عنوان ژورنال: Genetics
سال: 2020
ISSN: 1943-2631
DOI: 10.1534/genetics.119.302855